Lili Yang, Ph.D. – Department of Microbiology, Immunology ...

[email protected]. 310-825-8609. Terasaki Life Sciences Building (TLSB), 3032. Website. Affiliations. Associate Professor, Microbiology, Immunology ... X Home About Research People PrimaryFaculty JointFaculty EmeritusFaculty AdjunctFaculty TeachingFaculty Staff Education Graduate Overview GraduatePrograminBioscience IMMPHomeArea MicrobialPathogenesisTrainingGrant Undergraduate Overview PreparationforMajor DegreeRequirements ElectiveCourses SampleCurriculumOptions LaboratoryResearch Overview PATH1 PATH2 DepartmentHonors MIMG99and199 Counseling MIMG2022Commencement Events News Contacts/ConferenceRooms Career GIVENOW UCLA College LifeSciences DGSOM Home About Research People PrimaryFaculty JointFaculty EmeritusFaculty AdjunctFaculty TeachingFaculty Staff Education Graduate Overview GraduatePrograminBioscience IMMPHomeArea MicrobialPathogenesisTrainingGrant Undergraduate Overview PreparationforMajor DegreeRequirements ElectiveCourses SampleCurriculumOptions LaboratoryResearch Overview PATH1 PATH2 DepartmentHonors MIMG99and199 Counseling MIMG2022Commencement Events News Contacts/ConferenceRooms Career GIVENOW LatestNews LiliYang,Ph.D. AssociateProfessorliliyang@ucla.edu310-825-8609TerasakiLifeSciencesBuilding(TLSB),3032 Website Affiliations AssociateProfessor,Microbiology,Immunology&MolecularGenetics Member,Eli&EdytheBroadCenterforRegenerativeMedicineandStemCellResearch(BSCRC) Member,JonssonComprehensiveCancerCenter(JCCC) Member,MolecularBiologyInstitute(MBI) Member,Inflammation,Immunity,Infection&TransplantationTheme(I3T) Member,GPBHomeAreaImmunity,Microbes&MolecularPathogenesis(IMMP) ResearchInterests Ourresearchcentersondecipheringthemolecularmechanismscontrollingantitumorimmunity,andexploitingknowledgetodevicenewgene-andcell-basedcancerimmunotherapies. Wehavetwoactiveresearchdirections: Studyingthemolecularcontrolofantitumorimmunity. Developingnewgene-andcell-basedimmunotherapiesfortreatingcancer. Fordetails,pleasevisitourlabwebsite:https://www.liliyanglab.com/research/. Biography Dr.LiliYangiscurrentlyanAssociateProfessoratUCLA.ShereceivedherB.S.degreeinBiologyfromtheUniversityofScience&TechnologyofChina(USTC)in1997,herM.S.degreeinBiomedicalSciencesfromtheUniversityofCalifornia,Riverside(UCR)in1999,andherPh.D.degreeinBiologyfromtheCaliforniaInstituteofTechnology(Caltech)in2004.SheobtainedherPh.D.trainingattheLaboratoryofDavidBaltimore.Postgraduation,shestayedatCaltechandledamulti-institutionalEngineeringImmunityProgramfrom2004to2012,developinggene-andcell-basedimmunotherapiesforcancerandHIV/AIDS.ShejoinedtheUniversityofCalifornia,LosAngeles(UCLA)asanAssistantProfessorin2013.HerlaboratoryatUCLAstudiestumorimmunologyandcancerimmunotherapy,withaspecialfocusonstemcell-basedandgene-engineeredimmunotherapyforcancer.Herworkhasresultedinover35peer-reviewedpublications(inprestigiousjournalsincludingNature,NatureBiotechnology,CellStemCell,PNAS,JExpMed,JClinInvest,Blood,etc.),15patents,2clinicaltrials,and2biotechstartups. Inrecognitionofherscientificachievements,Dr.LiliYanghasreceivedmultipleprestigiousawards,includingtheTR35(InnovatorsUnder35)AwardfromtheMITTechnologyReviewMagazine,theForbeckScholarAward,theDirector’sNewInnovatorAwardfromtheNationalInstituteofHealth(NIH),theTranslationalResearchProjectAwardfromtheCaliforniaInstituteforRegenerativeMedicine(CIRM),theYoungInvestigatorAwardfromtheAmericanAssociationofImmunologists(AAI),andtheOutstandingNewInvestigatorAwardfromtheAmericanSocietyofGene&CellTherapy(ASGCT). Publications  Completepublicationlist: https://www.liliyanglab.com/publications/ Selectedpublications: DiBiaseS*,MaX*,WangX,YuJ,WangY-C,SmithDJ,ZhouY,LiZ,KimYJ,ClarkeN,ToA,andYangL.(Co-firstauthors). CreatineuptakeregulatesCD8Tcellantitumorimmunity. JExpMed.2019,216(12):2869-2882.Epub2019Oct18.[Link][PDF] ZhuY.*,SmithDJ*,ZhouY,LiYR,YuJ,LeeD,WangY-C,DiBiaseS,WangXi,HardoyC,KuJ,TsaoT,LinLJ,PhamAT,MoonH,McLaughlinJ,ChengD,HollisRP,Campo-FernandezB,UrbinatiF,WeiL,PangL,RezekV,Berent-MaozB,MacabaliMH,GjertsonD,WangX,GalicZ,KitchenSG,AnDS,Hu-LieskovanS,Kaplan-LefkoPJ,DeOliveiraSN,SeetCS,LarsonSM,FormanSJ,HeathJR,ZackJA,CrooksGM,RaduGR,RibasA,KohnDB,WitteON,andYangL.(Co-firstauthors). Developmentofhematopoieticstemcell-engineeredinvariantnaturalkillerTcelltherapyforcancer. CellStemCell.2019,25(4):542-557.Epub2019 Sept5.[Link][PDF][CSCHighlight] Puig-SausC,ParisiG,Garcia-DiazA,KrystofinskiPE,SandovalS,ZhangR,ChamphekarAS,McCabeJ,Cheung-LauGC,TruongNA,Vega-CrespoA,KomenanMDS,PangJ,MacabaliMH,SacoJD,GoodwinJL,BolonB,SeetCS,Montel-HagenA,CrooksGM,HollisRP,Campo-FernandezB,BischofD,CornettaK,GschwengEH,AdelsonC,NguyenA,YangL,WitteON,BaltimoreD,Comin-AnduixB,KohnDB,WangX,CabreraP,Kaplan-LefkoPJ,Berent-MaozB,andRibasA. IND-enablingstudiesforaclinicaltrialtogeneticallyprogramapersistentcancer-targetedimmunesystem. ClinCancerRes.2019,25(3):1000-1011.[Link][PDF] BethuneMT§,LiXH§,YuJ§,McLaughlinJ,ChengD,MathisC,MorenoBH,WoodsK,KnightsAJ,Garcia-DiazA,WongS,Hu-LieskovanS,SausCP,CebonJ,RibasA,YangL*,WitteON*,andBaltimoreD*.(§Co-firstauthors)(*Co-correspondingauthors). IsolationandcharacterizationofNY-ESO-1-specificTcellreceptorsrestrictedonvariousMHCmolecules. Proc.Natl.Acad.Sci.USA.2018,115(45):E107002-E10711.[Link][PDF] SieglerEL,ZhuY,WangP*,andYangL*.(*Co-correspondingauthors). Off-the-shelf CAR-NKcellsforcancerimmunotherapy. CellStemCell.2018,23(8):160-161.[Link][PDF] NowickiTS,Escuin-OrdinasH,AvramisE,ChmielowskiB,ChodonT,Berent-MaozB,WangX,Kaplan-LefkoP,YangL,BaltimoreD,EconomouJS,RibasA,andComin-AnduixB. CharacterizationofpostinfusionphenotypicdifferencesinfreshversuscryopreservedTCRengineeredadoptivecelltherapyproducts. JImmunother.2018,41(5):248-259.[Link][PDF] LiB*,WangX*,ChoiI,LiuS,PhamA,MoonH,RaoDS,BoldinMP,andYangL.(Co-firstauthors). miR-146amodulatesautoreactiveCD4TcellTh17differentiationandregulatesTcell-mediatedautoimmunity. JClinInvest.2017,127(10):3702-3716.[Link][PDF] KimJT,LiuY,KulkarniRP,LeeKK,DaiBB,LovelyG,OuyangY,WangP,YangL, andBaltimoreD. Dendriticcell-targetedlentiviralvectorimmunizationusespseudotransductionandDNA-mediatedSTINGandcGASactivation. SciImmunol.2017,2:eaal1329.[Link][PDF] SmithDJ,LinLJ,MoonH,PhamAT,WangX,LiuS,JiS,RezekV,ShimizuS,RuizM,LamJ,JanzenDM,MemarzadehS,KohnDB,ZackJA,KitchenSG,AnDS,andYangL. PropagatinghumanizedBLTmiceforthestudyofhumanimmunologyandimmunotherapy. StemCellsDev.2016,25(24):1863-1873.[Link][PDF] SmithDJ,LiuS,JiS,LiB,McLaughlinJ,ChengD,WitteON,andYangL. GeneticEngineeringofhematopoieticstemcellstogenerateinvariantnaturalkillerTcells. Proc.Natl.Acad.Sci.USA.2015,112(5):1523-28.[Link][PDF] ChodonT,Comin-AnduixB,ChmielowskiB,KoyaRC,WuZ,AuerbachM,NgC,AvramisE,SejaE,VillanuevaA,McCannelTA,IshiyamaA,CzerninJ,RaduCG,WangX,GjertsonDW,CochranAJ,CornettaK,WongDJL,Kaplan-LefkoP,HamidO,SamlowskiW,CohenPA,DanielsGA,MukherjiB,YangL,ZackJA,KohnDB,HeathJR,GlaspyJA,WitteON,BaltimoreD,EconomouJS,andRibasA. AdoptivetransferofMART-1T-cellreceptortransgeniclymphocytesanddendriticcellvaccinationinpatientswithmetastaticmelanoma. ClinCancerRes.2014,20(9):2457-65.[Link][PDF] YangL*andWangP.(*Correspondingauthor). PassiveimmunizationagainstHIV/AIDSbyantibodygenetransfer. Viruses.2014,6(2):428-47.[Link][PDF] HurEM,PatelSN,ShimizuS,RaoD,GnanapragasamPNP,AnDS,YangL*,andBaltimoreD*.(*Co-correspondingauthors). InhibitoryeffectofHIV-specificneutralizingIgAonmucosaltransmissionofHIVinhumanizedmice. Blood.2012,120(23):4571-82.[Link][PDF] YangL*,BoldinMP,YuY,LiuCS,EaCK,TaganovKD,ZhaoJL,andBaltimoreD*.(*Co-correspondingauthors). miR-146acontrolstheresolutionofTcellresponsesinmice. JExpMed.2012,209(9):1655-70.[Link][PDF] YuKK,AguilarK,TsaiJ,GalimidiR,GnanapragasamP,YangL, andBaltimoreD. Useof mutatedself-cleaving2Apeptidesasamolecularrheostattodirectsimultaneousformationofmembraneandsecretedanti-HIVimmunoglobulins. PLoSOne.2012,7(11):e50438.[Link][PDF] XiaoL,KimJ,LimM,DaiB,YangL,ReedS,BaltimoreD,andWangP. ATLR4agonistsynergizeswithdendriticcell-directedlentiviralvectorsforinducingantigen-specificimmuneresponses. Vaccine.2012,30(15):2570-81.[Link][PDF] BalazsAB,ChenJ,HongCM,RaoDS,YangL,andBaltimoreD. Antibody-basedprotectionagainstHIVinfectionbyvectoredimmunoprophylaxis. Nature.2011,481(7379):81-4.[Link][PDF] YangL*,YuY,KalwaniM,TsengTW,andBaltimoreD*.(*Co-correspondingauthors). HomeostaticcytokinesorchestratethesegregationofCD4andCD8memoryT-cellreservoirsinmice. Blood.2011,118(11):3039-50.[Link][PDF] BoldinMP,TaganovKD,RaoDS,YangL,ZhaoJL,KalwaniM,Garcia-FloresY,LuongM,DevrekanliA,XuJ,SunG,TayJ,LinsleyPS,BaltimoreD. miR-146aisasignificantbrakeonautoimmunity,myeloproliferation,andcancerinmice. JExpMed.2011,208(6):1189-201.[Link][PDF] LuoXM,LeiMY,FeidiRA,WestAPJr,BalazsAB,BjorkmanPJ,YangL*,BaltimoreD*.(*Co-correspondingauthors). Dimeric2G12asapotentprotectionagainstHIV-1. PLoSPathog.2010,6(12):e1001225.[Link][PDF] O’ConnellRM,BalazsAB,RaoDS,KivorkC,YangL*,andBaltimoreD*.(*Co-correspondingauthors). Lentiviralvectordeliveryofhumaninterleukin-7(hIL-7)tohumanimmunesystem(HIS)miceexpandsTlymphocytepopulations. PLoSOne.2010,5(8):e12009.[Link][PDF] BaltimoreD,WitteON,YangL,EconomouJ,andRibasA. Overcomingbarrierstoprogrammingatherapeuticcellularimmuneresponsetofightmelanoma. PigmentCellMelanomaRes.2010,23(2):288-9.[Link][PDF] DaiB,YangL,YangH,HuB,BaltimoreD,andWangP. HIV-1Gag-specificimmunityinducedbyalentivector-basedvaccinedirectedtodendriticcells. ProcNatlAcadSciUSA.2009,106(48):20382-7.[Link][PDF] LuoXM,MaarschalkE,O’ConnellRM,WangP,YangL*,andBaltimoreD*.(*Co-correspondingauthors). Engineeringhumanhematopoieticstem/progenitorcellstoproduceabroadlyneutralizinganti-HIVantibodyafterinvitromaturationtohumanBlymphocytes. Blood.2009,113(7):1422-31.[Link][PDF] ZieglerL,YangL,JooKi,YangH,BaltimoreD,andWangP. Targetinglentiviralvectorstoantigen-specificimmunoglobulins. HumGeneTher.2008,19(9):861-72.[Link][PDF] ChhabraA,YangL,WangP,Comin-AnduixB,DasR,ChakrabortyNG,RayS, MehrotraS,YangH,HardeeCL,HollisR,DorskyDI,KoyaR,KohnDB,RibasA, EconomouJS,BaltimoreD,andMukherjiB. CD4+CD25-TcellstransducedtoexpressMHCclassI-restrictedepitope-specificTCRsynthesizeTh1cytokinesandexhibitMHCclassI-restrictedcytolyticeffectorfunctioninahumanmelanomamodel. JImmunol.2008,181(2):1063-70.[Link][PDF] YangL*,YangH*,RideoutK,ChoT,JooKI,ZieglerL,ElliotA,WallsA,YuD,BaltimoreD**,andWangP**.(*Co-firstauthors).(**Co-correspondingauthors). Engineeredlentivectortargetingofdendriticcellsforinvivoimmunization. NatBiotechnol.2008,26(3):326-34.[Link][PDF] YangL,BaileyL,BaltimoreD*,andWangP*.(*Co-correspondingauthors). Targetinglentiviralvectorstospecificcelltypesinvivo. ProcNatlAcadSciUSA.2006,103(31):11479-84.[Link][PDF] YangLandBaltimoreD. Long-terminvivoprovisionofantigen-specificTcellimmunitybyprogramminghematopoieticstemcells. ProcNatlAcadSciUSA.2005,102(12):4518-23-34.[Link][PDF] BridgesR,RigeroB,ByrnesE,YangL,andWalkerA. Centralinfusionsoftherecombinanthumanprolactinreceptorantagonist,S179D-PRL,delaytheonsetofmaternalbehaviorinsteroid-primed,nulliparousfemalerats. Endocrinology.2001,142(2):730-9.[Link][PDF] YangL,KuoCB,LiuY,CossD,XuX,ChenC,Oster-GraniteML,andWalkerAM. Administrationofunmodifiedprolactin(U-PRL)andamolecularmimicofphosphorylatedprolactin(PP-PRL)duringratpregnancyprovidesevidencethattheU-PRL:PP-PRLratioiscrucialtothenormaldevelopmentofpuptissues. JEndocrinol.2001,168(2):227-38.[Link][PDF] CossD,YangL,KuoCB,XuX,LubenRA,andWalkerAM. Effectsofprolactinonosteoblastalkalinephosphataseandboneformationinthedevelopingrat. AmJPhysiolEndocrinolMetab.2000,279(6):E1216-25.[Link][PDF] CossD,KuoCB,YangL,IngletonP,LubenR,WalkerAM. DissociationofJanuskinase2andsignaltransducerandactivatoroftranscription5activationaftertreatmentofNb2cellswithamolecularmimicofphosphorylatedprolactin.Endocrinology. 1999,140(11):5087-94.[Link][PDF]